Turkish Journal of Physical Medicine and Rehabilitation 2013 , Vol 59 , Num 4

Isaacs’ Syndrome (Neuromyotonia) Associated With Peripheral Neuropathy

Canan Çelik 1 ,Sibel Mandıroğlu 2 ,Halil Uçan 3 ,Eser Başak Sevgi 4
1 Department of Physical Medicine and Rehabilitation, Bursa Şevket Yılmaz Education and Research Hospital, Bursa, Turkey
2 T.c. Sağlık Bakanlığı Ankara Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi, Ankara
3 Turkish Ministry of Health, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey
4 Ankara Fizik Tedavi Rehabilitasyon Eğitim Araştırma Hastanesi, Nöroloji Kliniği, Ankara, Türkiye
DOI : 10.4274/tftr.83435

Isaacs’s syndrome (neuromyotonia), which is characterized by peripheral nerve hyperexcitability, is a rare condition of spontaneous and continuous muscle fibre activity. This syndrome is associated with myokymia, muscle cramps and stiffness, delayed muscle relaxation after contraction, muscle weakness, and hyperhydrosis. We report two siblings with Isaacs’ syndrome associated with peripheral neuropathy gait disturbance, distal muscle weakness, neuromyotonia, muscle spasms, myokymia and hyperhydrosis. In both patients, neuromyotonic discharges were recorded by needle electromyography and axonal sensorimotor peripheral neuropathy was diagnosed electrophysiologically. In this study, a rare case of Isaacs’syndrome (neuromyotonia) associated with peripheral neuropathy is emphasized.

Keywords : Isaacs’ syndrome, neuromyotonia, peripheral neuropathy