Turkish Journal of Physical Medicine and Rehabilitation 2012 , Vol 58 , Num 4
Infliximab Treatment in Resistant Pyoderma Gangrenosum: A Case Report
Yunus Durmaz 1 ,Ayhan Bilgici 2 ,Erhan Erdem Cil 1 ,Ömer Kuru 2
1 Ondokuz Mayıs Üniversitesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Samsun, Türkiye
2 Ondokuz Mayıs Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Samsun, Türkiye
DOI : 10.4274/tftr.43760

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis consisting of nodules and pustules that ulcerate. Pyoderma gangrenosum is associated with autoimmune disorders such as inflammatory bowel disease, spondyloarthritis, and rheumatoid arthritis. In mild disease, therapy consists of local wound care and topical or intralesional corticosteroids. For more severe disease, systemic agents are necessary. Herein, we present the case of a patient with steroid resistant pyederma gangrenosum associated with ulcerative colitis and ankylosing spondylitis who responded well to infliximab, a tumor necrosis factor blocker. Biological agents (anti-TNF) may be alternative treatment options in patients with resistant PG. 

Keywords : Pyoderma gangrenosum; infliximab; anti-TNF