Turkish Journal of Physical Medicine and Rehabilitation 2012 , Vol 58 , Num 4
Etiopathogenesis of Osteoporosis in Rheumatic Diseases
Dilşad Sindel 1 ,Sina Esmaeilzadeh 2 ,Ekin İlke Şen 3
1 İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Algoloji Bölümü, İstanbul, Türkiye
2 İstanbul Üniversitesi İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye
3 İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye
DOI : 10.4274/tftr.48264

Various inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis and systemic lupus erythematosus are associated with musculoskeletal complications including osteoporosis. They are related to osteoporosis and increased risk of fractures independent of other risk factors like low physical activity, nutritional deficiency, hypovitaminosis D and inadequate calcium intake, as well as glucocorticoid treatment. The pathogenesis of osteoporosis in inflammatory diseases is multifactorial. The concept of osteoimmunology is based on growing insights into the relationship between the immune system and bone. The association between inflammation and osteoporosis can be explained by the link between osteoclast, macrophage colony stimulating factor and proinflammatory cytokines. Here we discuss the etiopathogenesis underlying the inflammatory loss of bone in rheumatoid arthritis, ankylosing spondylitis and systemic lupus erythematosus. 

Keywords : Osteoporosis; inflammation; rheumatoid arthritis; ankylosing spondylitis; systemic lupus erythematosus