Turkish Journal of Physical Medicine and Rehabilitation 2005 , Vol 51 , Num 2
Physiopathology of Pai
Işık Aydınlı 1
1 İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Anesteziyoloji ve Reanimasyon Anabilim Dalı, Ağrı Bilim Dalı, İstanbul

For pain sensation, a squence of electrical and chemical process may occur in peripheral and central nervous system when noxious stimulus is present. Activation starting with noxious stimulus cause molecular, cellular, genetic and neurobiological changes as from the beginning. These changes are important especially in chronic pain. It is asserted that immune system both peripherally and centrally (with neural immune cells- spinal cord glia cells; microglia and astrocytes) play important role in pathological variation of sensorial system. In addition, the role of brain in the structure of nervous system related with pain is gradually getting more important. The brain structure related with pain (neuromatrix) are processed genetically after than formed with stres and emotions. Finally pain is percieved multidimentially and constituted by behavioral and homeostatic response and so individual neural signature is formed. 

Keywords : Pain, physiopathology