Fibromyalgia syndrome (FMS) is a multisystem disorder, characterized by
widespread pain that is usually associated with hyperalgesia and allodynia.
Comorbidities such as fatigue, stiffness, insomnia, depression and anxiety
make its classification and treatment difficult. The confluence of pain and
other symptoms and conditions such as fatigue, depression, sleep
disturbance and cognitive dysfunction contribute to the reduced function
and quality of life in patients with FMS. Clinical trials have shown that
optimum benefit may be obtained only with therapeutic strategies
including both pharmacological and non-pharmacological interventions
taking into consideration pain severity, symptoms and functional status.
The aim of this review was to summarize the current literature on
pharmacological and non-pharmacological treatments of FMS as well as to
evaluate the evidence of the value of the available treatment interventions.
Turk J Phys Med Re hab 2012;58:136-42.