Turkish Journal of Physical Medicine and Rehabilitation

Membranous nephropathy in a patient with ankylosing spondylitis: A rare renal manifestation or just a coincidence?

Ebru Köseoğlu Tohma 1 ,Feride Göğüş 2
1 Department of Physical Medicine and Rehabilitation, Muğla Sıtkı Koçman University Training and Research Hospital, Muğla, Turkey
2 Department of Physical Medicine and Rehabilitation, Gazi University Faculty of Medicine, Ankara, Turkey
DOI : 10.5606/tftrd.2022.8801 Renal involvement in ankylosing spondylitis (AS) is uncommon and usually secondary to amyloidosis or analgesic nephropathy. A 41-yearold female patient who was diagnosed with human leukocyte antigen-B27-positive AS 16 years ago was admitted to the rheumatology outpatient clinic with pretibial and pedal edema. She had nephrotic-range proteinuria. Renal biopsy findings confirmed the diagnosis of membranous nephropathy. Extensive malignancy evaluation was negative. Edema regressed, renal functions stabilized, and proteinuria reduced within two months after immunosuppressive therapy. Keywords : Ankylosing spondylitis, glomerulonephritis, membranous nephropathy, nephrotic syndrome, proteinuria, spondyloarthritis