Turkish Journal of Physical Medicine and Rehabilitation
Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures? Bilateral atypical femoral fractures following bisphosphonate use in members of the same family
Mehmet Okçu 1 ,Fatmanur Aybala Koçak 1 ,Samet Sancar Kaya 1 ,Figen Tuncay 1
1 Department of Physical Medicine and Rehabilitation, Ahi Evran University School of Medicine, Kırşehir, Turkey DOI : 10.5606/tftrd.2021.5248 Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data. Keywords : Atypical femoral fracture, bisphosphonate, genetic factor